Icatibant (acetate) (Synonyms: HOE 140) |
| رقم الكتالوجGC43888 |
Icatibant (acetate) (HOE-140 acetate) هو مضاد ببتيد قوي ومحدد لمستقبل bradykinin B2 مع IC50 و Ki 1.07 نانومتر و 0.798 نانومتر على التوالي.
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Cas No.: 138614-30-9
Sample solution is provided at 25 µL, 10mM.
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Icatibant is a synthetic peptide antagonist of the bradykinin B2 receptor with IC50 and Ki values of 1.07 and 0.798 nM, respectively, in guinea pig ileal cell membranes. It inhibits bradykinin-induced contractions in isolated guinea pig ileum and pulmonary arteries as well as in rat uterus (IC50s = 11, 5.4, and 4.9 nM, respectively). In vivo, icatibant inhibits bronchoconstriction induced by bradykinin in a guinea pig model (ID50s = 13.4 and 31.8 pmol/kg, i.v., for pulmonary resistance and dynamic lung compliance, respectively). Icatibant (30 µg, i.v.) also reduces vascular permeability in the footpad and intestine in a mouse model of hereditary angioedema. Formulations containing icatibant have been used for the treatment of hereditary angioedema.
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