IRE1α kinase-IN-2 |
| رقم الكتالوجGC64232 |
IRE1α ؛ كيناز إن -2 هو IRE1α فعال ؛ مثبط كيناز ، مع EC50 من 0.82 μ ؛ M. IRE1α ؛ يثبط كيناز إن -2 IRE1α ؛ الفسفرة الذاتية للكيناز (IC50 = 3.12 μ ؛ M). IRE1α ؛ kinase-IN-2 يمنع XBP1 mRNA splicing في خطوط خلايا WT.
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Cas No.: 1414938-21-8
Sample solution is provided at 25 µL, 10mM.
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IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines[1].
IRE1α kinase-IN-2 (compound 3) inhibits XBP1 mRNA splicing, even during ER stress[1].
[1]. Wang L, Perera BG, Hari SB, et al. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012;8(12):982-989.
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