JAK 3i |
| رقم الكتالوجGC70213 |
JAK 3i هو انتقائي للغاية المانع من jak3 ( ic50 : 0.43nm ) .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1918238-72-8
Sample solution is provided at 25 µL, 10mM.
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JAK3i is a highly selective JAK3 inhibitor (IC50: 0.43 nM). JAK3i forms a covalent bond with a cysteine in JAK3, but not the closely related kinase domains in JAK1, JAK2, or TYK2. JAK3i abolishes IL-2-driven T-cell proliferation in vivo and has the potential for autoimmune disease research.
References:
[1]. Geoffrey A Smith, et al. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nat Chem Biol. 2016 May;12(5):373-9.
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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