JG-98 |
رقم الكتالوجGC34634 |
JG-98 ، مثبط بروتين 70 (Hsp70) لصدمة الحرارة الخيفية ، والذي يرتبط بإحكام بموقع محفوظ على Hsp70 ويعطل تفاعل Hsp70-Bag3يُظهر JG-98 الأنشطة المضادة للسرطان التي تؤثر على كل من الخلايا السرطانية والضامة المرتبطة بالورم
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Cas No.: 1456551-16-8
Sample solution is provided at 25 µL, 10mM.
JG-98 is a heat shock protein 70 (Hsp70) Inhibitor with anti-cancer activities[1][2]. Heat shock protein 70[1]
JG-98 inhibits the breast cancer cell lines MDA-MB-231 and MCF-7 with EC50 values of 0.4 and 0.7 μM, respectively[1].
[1]. Yaglom JA, et al. Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and findingsynergistic drug combinations. Sci Rep. 2018 Feb 14;8(1):3010.
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