K-(D-1-Nal)-FwLL-NH2 |
| رقم الكتالوجGC50274 |
K- (D-1-Nal) -FwLL-NH2 هو ناهض لمستقبلات الجريلين القوية والعاكسة عالية التقارب (EC50 = 3.4 نانومتر ، Ki = 4.9 نانومتر)
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Cas No.: 1394288-22-2
Sample solution is provided at 25 µL, 10mM.
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High affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). Blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.
Els et al (2012) An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J.Med.Chem. 55 7437 PMID:22920150 |M'Kadmi et al (2015) Agonism, antagonism, and inverse agonism bias at the ghrelin receptor signaling. J.Biol.Chem. 290 27021 PMID:26363071
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