KDM5-C70 (Synonyms: KDOAM-21) |
| رقم الكتالوجGC39394 |
KDM5-C70 هو مشتق إيثيل إيثيل من KDM5-C49 ومثبط قوي ، ونفاذي للخلايا ، ومثبط هيستون دي ميثيلاز KDM5KDM5-C70 له تأثير مضاد للتكاثر في خلايا الورم النقوي ، مما يؤدي إلى ارتفاع مستويات H3K4me3 على مستوى الجينوم
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Cas No.: 1596348-32-1
Sample solution is provided at 25 µL, 10mM.
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KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels[1][2].
[1]. Johansson C, et al. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12(7):539-45. [2]. Blair LP, et al. KDM5 lysine demethylases are involved in maintenance of 3'UTR length. Sci Adv. 2016 Nov 18;2(11):e1501662.
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