Koningic acid (Synonyms: (2'S,5aS,6R,9aS)-1,5a,6,7,8,9a-Hexahydro-6-(1-methylethyl)-1-oxo-spiro[2-benzoxepin-9(3H)2'-oxirane]-4-carboxylic acid) |
| رقم الكتالوجGB40253 |
Koningic acid (KA; 74310-84-2) is a potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Inhibition is irreversible and proceeds via nucleophilic attack of an active site cysteine on the epoxide moiety, Ki = 1.1 μM for rabbit muscle GAPDH. KA can selectively kill high-glycolytic cancer cells via glucose dependent ATP depletion. Has been used in a predictive model for selective targeting of the Warburg effect, the most prominent hallmark of cancer cell metabolism.
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Cas No.: 74310-84-2
Sample solution is provided at 25 µL, 10mM.
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Koningic acid (KA; 74310-84-2) is a potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Inhibition is irreversible and proceeds via nucleophilic attack of an active site cysteine on the epoxide moiety, Ki = 1.1 μM for rabbit muscle GAPDH. KA can selectively kill high-glycolytic cancer cells via glucose dependent ATP depletion. Has been used in a predictive model for selective targeting of the Warburg effect, the most prominent hallmark of cancer cell metabolism.
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