L-Homopropargylglycine hydrochloride (Synonyms: HPG) |
| رقم الكتالوجGC63043 |
L-Homopropargylglycine hydrochloride عبارة عن رابط PROTAC قائم على سلسلة ألكيل يمكن استخدامه في تخليق PROTACsL-homopropargylglycine hydrochloride هو نظير من الأحماض الأمينية للميثيونين يحتوي على جزء ألكين يمكن أن يخضع لتفاعل كيميائي كلاسيكي مع أزيد يحتوي على Alexa Fluor
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Cas No.: 942518-19-6
Sample solution is provided at 25 µL, 10mM.
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L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor[1][2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018;36:553-562.
[2]. Shen Y, et al. Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes. STAR Protoc. 2021;2(3):100616. Published 2021 Jun 17.
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