Lanicemine dihydrochloride |
| رقم الكتالوجGC61842 |
Lanicemine (AZD6765) ثنائي هيدروكلوريد هو مانع قناة NMDA منخفض الاحتباس (Ki 0.56-2.1 ميكرومتر لمستقبل NMDA ؛ IC50s من 4-7 ميكرومتر و 6.4 ميكرومتر في خلايا البويضات CHO و Xenopus ، على التوالي).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 153322-06-6
Sample solution is provided at 25 µL, 10mM.
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Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 µM for NMDA receptor; IC50s of 4-7 µM and 6.4 µM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].
Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1].Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1].
References:
[1]. Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85.
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