Laulimalide |
| رقم الكتالوجGC50052 |
Microtubule stabilzing agent
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 115268-43-4
Sample solution is provided at 25 µL, 10mM.
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Microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles.
Pryor et al (2002) The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to PacT. and epothilones, and may not require its epoxide moiety for activity. Biochemistry. 41 9109 PMID:12119025 |Bennett et al (2012) Low-dose laulimalide represents a novel molecular probe for investigating microtubule organization. Cell Cycle. 11 3045 PMID:22871740 |Bennett et al (2010) Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping. Chem.Biol. 17 725 PMID:20659685
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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