LEI-110 |
| رقم الكتالوجGC52080 |
LEI-110 هو مثبط عمومي قوي وانتقائي ومنفذ للخلايا من عائلة HRASLS من هيدروليسات ثيول.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2313525-90-3
Sample solution is provided at 25 µL, 10mM.
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LEI-110 is an inhibitor of adipose phospholipase A2 (AdPLA2; IC50 = 100 nM).1 It also inhibits HRas-like suppressor 2 (HRASL2), retinoid acid receptor responder protein 3 (RARRES3), and calcium-independent N-acyltransferase (iNAT; IC50s = 158, 158, and 25 nM, respectively). LEI-110 (10 µM) decreases arachidonic acid levels in U2OS cells expressing human AdPLA2 and prevents oleic acid-induced increases in lipid droplet formation in HepG2 cells.
1.Zhou, J., Mock, E.D., Martella, A., et al.Activity-based protein profiling identifies α-ketoamides as inhibitors for phospholipase A2 group XVIACS Chem. Biol.14(2)164-169(2019)
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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