Lipid peroxidation inhibitor 1 |
رقم الكتالوجGC31275 |
مثبط بيروكسيد الدهون 1 هو مثبط بيروكسيد الدهون مع IC50 0.07 ميكرومتر
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Cas No.: 142873-41-4
Sample solution is provided at 25 µL, 10mM.
Lipid peroxidation inhibitor 1 is a lipid peroxidation inhibitor with an IC50 of 0.07 μM.
Among the compounds synthesized, Lipid peroxidation inhibitor 1 (26n) exhibits potent effects in the inhibition of lipid peroxidation, with an IC50 of 0.07 μM[1].
Basic molecules 8a and 27 exhibit significant effects against (methamphetamine) MAP-induced hypermotility. Except in these compounds, a phenyl group adjacent to the methyl group in position 2 at a distance seems to be indispensable (compare compounds 26m, o, p with compounds Lipid peroxidation inhibitor 1 (26n), q, r). Among these compounds, Lipid peroxidation inhibitor 1 which has a phenylpiperidinyl group in position 2 is found to be most effective[1].
[1]. Ohkawa S, et al. 5-aminocoumarans: dual inhibitors of lipid peroxidation and dopamine release with protectiveeffects against central nervous system trauma and ischemia. J Med Chem. 1997 Feb 14;40(4):559-73.
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