m-PEG5-CH2COOH |
رقم الكتالوجGC65825 |
إن m-PEG5-CH2COOH عبارة عن رابط ADC غير قابل للانشقاق يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs). m-PEG5-CH2COOH هو أيضًا رابط PROTAC قائم على PEG ويمكن استخدامه في تركيب PROTACs.
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Cas No.: 16142-03-3
Sample solution is provided at 25 µL, 10mM.
m-PEG5-CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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