M190S |
| رقم الكتالوجGC73619 |
M190S هو جزيء صغير جديد يحمي الخلايا من موت الخلايا المعتمد على الميتوكوندريا سواء في المختبر أو في الجسم الحي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2578300-07-7
Sample solution is provided at 25 µL, 10mM.
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M190S is a novel small molecule protecting cells from mitochondria-dependent apoptosis both in vitro and in vivo. M190S has the potential to become a research tool for studying cell death mechanisms and to develop therapeutics targeting mitochondria-dependent cell death pathway. M190S has orally bioactivity with excellent brain permeability.
M190S (0.1-10000 nM, 24-48 h) inhibits apoptosis induced by Bax as well as Bak[1].M190S (0-10μM, 4 h) suppresses Staurosporine -induced apoptosis in MEFs [1].M190S (0-10μM, 24 h) inhibits Etoposide -induced apoptosis in Neuro2a cells[1].M190S (500 nM, 24 h) inhibits Obatoclax -induced apoptosis in ARPE19 cells[1].M190S (500 nM, 48 h) suppresses the conformation change (N-terminal exposure) and mitochondrial translocation of Bax[1].M190S (1.0 μM, 4h) decreases mitochondrial oxygen consumption and reactive oxygen species, whereas M190S (0.1-1 nM, 4 h) increases glycolysis[1].
M190S (10mg/kg p.o., three time in 48 h) protects the retina from the bright-light-induced photoreceptor death[1].M190S (1 mg/kg, i.p., i.v., 5 mg/kg, o.p. 10 mg/kg 1 time) is an orally bioactive cell death inhibitor penetrating blood-brain/retina-barrier[1].
References:
[1]. Mieko Matsuyama, et al. Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death. Science 26, 107916, October 20, 2023
| Cas No. | 2578300-07-7 | SDF | |
| Formula | C21H21N5O2 | M.Wt | 375.42 |
| الذوبان | DMSO : 100 mg/mL (266.37 mM; Need ultrasonic) | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6637 mL | 13.3184 mL | 26.6368 mL |
| 5 mM | 0.5327 mL | 2.6637 mL | 5.3274 mL |
| 10 mM | 0.2664 mL | 1.3318 mL | 2.6637 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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