Malachite green oxalate |
| رقم الكتالوجGC61021 |
أكسالات أخضر المالاكيت عبارة عن صبغة تراي فينيل ميثان يمكن استخدامها للكشف عن إطلاق الفوسفات في التفاعلات الأنزيميةأوكسالات الملاكايت الخضراء هي أيضًا مثبط قوي وانتقائي لـ IKBKE ، وتثبط أهدافها النهائية مثل IκBα و p65 و IRF3تظهر أكسالات الملاكايت الخضراء نشاطًا مضادًا للأورام في المختبر وفي الجسم الحي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2437-29-8
Sample solution is provided at 25 µL, 10mM.
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Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo[1][2][3].
[1]. Kozuka S, et, al. Permeability of dormant spores of Bacillus subtilis to malachite green and crystal violet. J Gen Microbiol. 1991 Mar; 137(3): 607-13. [2]. Takahashi S, et, al. Reversible off-on fluorescence probe for hypoxia and imaging of hypoxia-normoxia cycles in live cells. J Am Chem Soc. 2012 Dec 5; 134(48): 19588-91. [3]. Liu T, et, al. Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE. Cytokine. 2019 Apr; 116: 78-87.
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