MCC |
| رقم الكتالوجGC64470 |
MCC عبارة عن رابط ADC غير قابل للكسر يستخدم في تخليق اتحادات الأدوية والأجسام المضادة (ADCs) ، مثل MCC-DM1
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Cas No.: 104676-09-7
Sample solution is provided at 25 µL, 10mM.
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MCC is non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as MCC-DM1[1].
Antibody-drug conjugates (ADCs) are potent cytotoxic drugs linked to antibodies through chemical linkers, and allow specific targeting of drugs to neoplastic cells. Anti-CD22-MCC-DM1 is broadly effective in vitro against multiple NHL cell lines[1].
[1]. Polson AG, et al. Anti-CD22-MCC-DM1: an antibody-drug conjugate with a stable linker for the treatment of non-Hodgkin's lymphoma. Leukemia. 2010;24(9):1566-1573.
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