MeOSuc-Ala-Ala-Pro-Val-AMC (Synonyms: I 1270, MeOSucAAPVAMC, Methoxy SuccinylAlaAlaProValAMC) |
رقم الكتالوجGC44157 |
MeOSuc-Ala-Ala-Pro-Val-AMC عبارة عن ركيزة فلوروجينية لخلايا الكريات البيض البشرية وإيلاستاز البنكرياس الخنازير (كم: 362 μ ؛ M ، Ex = 380 نانومتر ، Em = 460 نانومتر).
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Cas No.: 72252-90-5
Sample solution is provided at 25 µL, 10mM.
MeOSuc-Ala-Ala-Pro-Val-AMC (MeOSuc-AAPV-AMC) is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase. The methoxy succinyl (MeO-Suc) peptide AAPV is avidly hydrolyzed by these elastases but not by cathepsin G. The addition of 7-amino-4-methylcoumarin (AMC) generates a peptide of low fluorescence (excitation: 355-380 nm; emission 440-460 nm) that demonstrates a linear increase in fluorescence in the presence of elastase. This peptidyl-AMC substrate detects as little as 11 pM human leukocyte elastase and 18 pM porcine pancreatic elastase.
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