ML-184 (Synonyms: CID-2440433) |
| رقم الكتالوجGC44217 |
ML-184 (CID2440433) هو ناهض GPR55 انتقائي مع EC50 من 250 نانومتر ويعرض> انتقائية 100 ضعف لـ GPR55 عبر GPR35 و CB1 و CB2
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 794572-10-4
Sample solution is provided at 25 µL, 10mM.
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GPR55 is a G protein-coupled receptor that is weakly activated by some cannabinoids (CBs) at nM concentrations but displays a 5- to 10-fold greater stimulation in response to 1 µM lysophosphatidylinositol (LPI). ML-184 is a potent synthetic agonist of GPR55 (EC50 = 0.26 µM). It does not act at the related kynurenic acid receptor GPR35 and is a weak antagonist of CB1 and CB2 (IC50s = 21.8 and 15.1 µM, respectively). Like LPI, ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55.
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