Mobocertinib (Synonyms: AP32788, TAK-788) |
رقم الكتالوجGC47697 |
Mobocertinib (TAK-788) هو مثبط EGFR / HER2 نشط عن طريق الفم ولا رجعة فيهMobocertinib يثبط بقوة المتغيرات السرطانية التي تحتوي على تنشيط طفرات EGFRex20ins مع انتقائية على EGFR من النوع البرييمكن استخدام Mobocertinib في أبحاث NSCLC
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Cas No.: 1847461-43-1
Sample solution is provided at 25 µL, 10mM.
Mobocertinib is an inhibitor of mutant EGFR and HER2 receptors.1,2 It is selective for the HER2 exon 20 mutants HER2V659E, HER2G660D, HER2G309E, and HER2S310F over wild-type EGFR in Ba/F3 cells.1
1.Chouitar, J., Vincent, S., Brake, R., et al.TAK-788 is a novel and potent tyrosine kinase inhibitor with selective activity against EGFR/HER2AbstractsS811P2(13-32)(2018) 2.Neal, J., Doebele, R., Riely, G., et al.Safety, PK, and preliminary antitumor activity of the oral EGFR/HER2 exon 20 inhibitor TAK-788 in NSCLCAbstractsS599P1(13-44)(2018)
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