Moxidectin (Synonyms: CL-301423) |
| رقم الكتالوجGC17083 |
Moxidectin (ProHeart 6؛ CL301423؛ Cydectin) هو دواء مضاد للديدان يقتل الديدان الطفيلية (الديدان الطفيلية) ، ويستخدم للوقاية من الديدان القلبية والديدان المعوية ومكافحتها
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 113507-06-5
Sample solution is provided at 25 µL, 10mM.
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Moxidectin(ProHeart 6; CL301423; Cydectin) is an anthelmintic drug which kills parasitic worms (helminths), and is used for the prevention and control of heartworm and intestinal worms.IC50 value:Target: Anti-parasiticMoxidectin is a semisynthetic derivative of nemadectin, which is produced by fermentation by Streptomyces cyano-griseus. Moxidectin treats and controls some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite. Studies of moxidectin show the side effects vary by animal and may be affected by the product’s formulation, application method and dosage.
References:
[1]. Moxidectin, From Wikipedia
| Cas No. | 113507-06-5 | SDF | |
| المرادفات | CL-301423 | ||
| Canonical SMILES | CC(/C([H])=C([C@](O1)([H])[C@@](/C(C[C@@]21C[C@](O3)([H])C[C@@](O2)([H])C/C([H])=C(C[C@@](/C([H])=C([H])/C([H])=C([C@@]45O)\CO[C@]5([H])[C@@](O)([H])C(C)=C[C@@]4([H])C3=O)([H])C)\C)=N\OC)([H])C)\C)C | ||
| Formula | C37H53NO8 | M.Wt | 639.82 |
| الذوبان | ≥ 129.4 mg/mL in DMSO, ≥ 128 mg/mL in EtOH, ≥ 3.27 mg/mL in Water with ultrasonic and warming | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.5629 mL | 7.8147 mL | 15.6294 mL |
| 5 mM | 0.3126 mL | 1.5629 mL | 3.1259 mL |
| 10 mM | 0.1563 mL | 0.7815 mL | 1.5629 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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