Mutant IDH1-IN-1 |
| رقم الكتالوجGC10485 |
المتحولة IDH1-IN-1 هي مثبط IDH1 انتقائي متحور مع IC50s من 4 و 42 و 80 و 143 نانومتر ضد متحولة IDH1 R132C / R132C و IDH1 R132H / R132H و IDH1 R132H / WT والنوع البري IDH1 ، على التوالي
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Cas No.: 1355326-21-4
Sample solution is provided at 25 µL, 10mM.
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Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.
References:
[1]. Deng G, et al. Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule. J Biol Chem. 2015 Jan 9;290(2):762-74.
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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