N-(Azido-PEG3)-N-Boc-PEG4-acid |
| رقم الكتالوجGC66807 |
N- (Azido-PEG3) -N-Boc-PEG4-acid عبارة عن رابط PROTAC قائم على PEG مع مجموعة أزيد الطرفية ويستخدم في تخليق PROTACs
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Cas No.: 2112731-95-8
Sample solution is provided at 25 µL, 10mM.
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N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker with a terminal azide group and is used in the synthesis of PROTACs[1]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Kanazaki K, et al. Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging. J Control Release. 2016 Mar 28;226:115-23.
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