N-(Azido-PEG4)-N-bis(PEG4-NHS ester) |
| رقم الكتالوجGC66631 |
N- (Azido-PEG4) -N-bis (PEG4-NHS ester) عبارة عن رابط PROTAC قائم على PEG يمكن استخدامه في تخليق PROTACs.
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Cas No.: 2353409-90-0
Sample solution is provided at 25 µL, 10mM.
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N-(Azido-PEG4)-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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