N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 |
| رقم الكتالوجGC67254 |
N- (m-PEG4) -N' ؛-( m-PEG4) -O- (m-PEG4) -O' ؛- (propargyl-PEG4) -Cy5 عبارة عن رابط PROTAC قائم على PEG يمكن استخدامه في تركيب بروتاكس.
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Cas No.: 2107273-54-9
Sample solution is provided at 25 µL, 10mM.
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N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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