N7-Me-GTP, 100mM Sodium Solution |
| رقم الكتالوجGB10790 |
N7-Me-GTP is a positively charged methyl-modified GTP that can be cotranscriptionally added to the 5′ cap.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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N7-Methylguanosine-5'-triphosphate(N7-Me-GTP, m7G)is a positively charged RNA modification that is co-transcriptionally added to the 5′cap during the initial stages of transcription and prior to other RNA processing events[1]. N7-Me-GTP regulates the transcription, splicing, nuclear export and translation of mRNA, and plays an important role in gene expression, protein synthesis and transcript stability[2]. The N7-Me-GTP modification is also found in tRNA and rRNA, and its presence is associated with various diseases [2].
References:
[1]. Bowen Song, et al. m7GHub: deciphering the location, regulation and pathogenesis of internal mRNA N7-methylguanosine (m7G) sites in human. Bioinformatics, Volume 36, Issue 11, June 2020, Pages 3528-3536.
[2]. Li-Sheng Zhang, et al. Transcriptome-wide Mapping of Internal N7-methylguanosine Methylome in Mammalian Messenger RNA. Published online 2019 Apr 25. DOI:10.1016/j.molcel.2019.03.036.
| purity | ≥99% | Extinction Coefficient | |
| Formula | C11H18N5O14P3(free acid) | M.Wt | 537.22(free acid) |
| Salt Form | تركيز | ||
| Buffer | Storage | -20℃ | |
| المرادفات | N7- methylguanosine -5'- triphosphate | Backbone | |
| Base Analog | Sugar Type | ||
| Nucleotide Category |
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