NADH-IN-1 |
| رقم الكتالوجGC70952 |
NADH-IN-1 لديه NADH: يوبيكوينون أوكسيدوريكتاز النشاط المثبط مع قيمة IC50 من 27 ميكرومتر.
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Cas No.: 1432445-15-2
Sample solution is provided at 25 µL, 10mM.
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NADH-IN-1 (1 μM) exhibits a short half-life and fast intrinsic clearance indicating that it is readily metabolised by the liver in vivo; shows no adverse effects on primary rat hepatocytes, and does not inhibit the hERG channel[1].
NADH-IN-1 (10 mg/kg; IV or PO; single dosage) produces no observable toxic effects at 10 mg/kg by IV or PO; exhibits a short half-life and high plasma clearance; exhibits high mouse and human serum protein binding, as well as moderate bioavailability[1].
References:
[1]. Devine R, et al. Design, synthesis, and biological evaluation of aryl piperazines with potential as antidiabetic agents via the stimulation of glucose uptake and inhibition of NADH:ubiquinone oxidoreductase. Eur J Med Chem. 2020;202:112416.
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