Nalidixic acid (Synonyms: NSC 82174, WIN 18,320) |
| رقم الكتالوجGC12455 |
حمض الناليديكسيك ، مضاد حيوي من الكينولون ، فعال ضد البكتيريا موجبة الجرام وسالبة الجرام
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 389-08-2
Sample solution is provided at 25 µL, 10mM.
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Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum.Target: AntibacterialNalidixic acid is the first of the synthetic quinolone antibiotics. Nalidixic acid is effective against both gram-positive and gram-negative bacteria. In lower concentrations, it acts in a bacteriostatic manner; that is, it inhibits growth and reproduction. In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth. Nalidixic selectively and reversibly blocks DNA replication in susceptible bacteria. Nalidixic acid and related antibiotics inhibit a subunit of DNA gyrase and topoisomerase IV and induce formation of cleavage complexes. It also inhibits the nicking-closing activity on the subunit of DNA gyrase that releases the positive binding stress on the supercoiled DNA. From Wikipedia.
References:
[1]. http://en.wikipedia.org/wiki/Nalidixic_acid
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