NFAT inhibitor, Cell Permeable |
| رقم الكتالوجGC50243 |
مثبط NFAT ، نفاذية الخلية هي عامل نووي منفذ للخلايا من مثبط الخلايا التائية المنشطة (NFAT).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 592517-80-1
Sample solution is provided at 25 µL, 10mM.
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NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice. Cell permeable.
Elloumi et al (2012) A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One 7 e34172 PMID:22479554 |Noguchi et al (2004) A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat.Med. 10 305 PMID:14770176
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
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