NMS-859 |
| رقم الكتالوجGC32874 |
NMS-859 هو مثبط VCP تساهمي قوي (p97) ، مع IC50s 0.37 و 0.36 ميكرومتر لـ VCP من النوع البري في وجود 60 ميكرومتر و 1 ملي ATP في الخلايا ، على التوالي
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Cas No.: 1449236-96-7
Sample solution is provided at 25 µL, 10mM.
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NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
NMS-859 is a potent VCP inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. NMS-859 shows very weak inhibitory activity against VCPC522T. NMS-859 also suppresses the proliferation of cells, with IC50s of 3.5 μM and 3.0 μM in HCT116 and HeLa cell lines, respectively[1].
[1]. Magnaghi P, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56.
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