الصفحة الرئيسية>>Signaling Pathways>> Membrane Transporter/Ion Channel>> Potassium Channel>>NPBA

NPBA

رقم الكتالوجGC70811

NPBA، ناهض لقناة البوتاسيوم K2P TASK-3 (KCNK9)، هو مجال مسامي ترادفي ضعيف داخليًا مانع لقناة K+ (TWIK2).

Products are for research use only. Not for human use. We do not sell to patients.

NPBA التركيب الكيميائي

Cas No.: 524033-40-7

الحجم السعر المخزون الكميّة
5 mg
86٫00
متوفر
10 mg
135٫00
متوفر
25 mg
279٫00
متوفر
50 mg
446٫00
متوفر
100 mg
716٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com

مراجعات العميل

بناء على آراء العملاء.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
NPBA, a potassium K2P channel TASK-3 (KCNK9) agonist, is a tandem pore domain weak inward rectifying K+ channel (TWIK2) channel blocker. NPBA suppresses NLRP3 inflammasome activation in macrophages.

References:
[1]. Fuyun Tian, et al. A Small-Molecule Compound Selectively Activates K2P Channel TASK-3 by Acting at Two Distant Clusters of Residues. Mol Pharmacol. 2019 Jul;96(1):26-35.
[2]. Yuanxing Zhi, et al. A novel TWIK2 channel inhibitor binds at the bottom of the selectivity filter and protects against LPS-induced experimental endotoxemia in vivo. Biochem Pharmacol. 2023 Dec:218:115894.

مراجعات

Review for NPBA

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for NPBA

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.