NSC-47924 (Synonyms: 1-((4-Methoxyanilino)methyl)-2-naphthol) |
| رقم الكتالوجGB40301 |
NSC-47924 (6638-24-0) is a potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 μM).
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Cas No.: 6638-24-0
Sample solution is provided at 25 µL, 10mM.
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NSC-47924 (6638-24-0) is a potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 μM). Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67 kDa laminin receptor (LR) interaction with laminin (LM) and selectively blocks LR-293 cell adhesion to LM (IC50=19.35 μM) impairing cell migration and invasion. Affects 37/67 kDa LR cell surface localization and interaction with cellular prion protein.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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