Obidoxime dichloride (Synonyms: Toxogonin) |
| رقم الكتالوجGC63305 |
ثنائي كلوريد أوبيدوكسيم هو عامل أوكسيم غير كامل الطيف ويمكن استخدامه كمضاد للتسمم بعامل الأعصاب الفوسفاتي العضوي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 114-90-9
Sample solution is provided at 25 µL, 10mM.
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Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated[1].
Obidoxime dichloride (intramuscular injection; 10 mg/kg; after 60 mins) exhibits a LD50 of 57.7 mg/kg after administration of sarin, and it reduces reduces acute toxicity of sarin was evaluated[1].
[1]. Kassa J,et al. A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.Toxicol Mech Methods. 2015 Mar;25(3):229-33.
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