OK2 |
| رقم الكتالوجGC72263 |
OK2، وهو مثبط خاص لتفاعل CCN2/EGFR، يمنع بكفاءة تفاعل CCN2/EGFR من خلال الارتباط بمجال CT من CCN2.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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OK2 (0-100 μM; 24 hours) inhibits EGFR activation, STAT3 phosphorylation, and ECM protein synthesis in HK-2 cells[1].
OK2 (50 μg/kg, i.p., for 14 days) blocks CCN2-induced EGFR/STAT3 activation and impede kidney fibrosis in the unilateral ureteric obstruction (UUO) mice model[1].
OK2 (1 mg/kg, s.c.) shows a T1/2 of 0.9 h and Cmax of 1057.8 ng/mL in male Sprague Dawley rats[1].
Pharmacokinetic parameters for OK2 in male Sprague Dawley rats [1]
References:
[1]. Dong J, et.al. Discovery and Design of Novel Cyclic Peptides as Specific Inhibitors Targeting CCN2 and Disrupting CCN2/EGFR Interaction for Kidney Fibrosis Treatment. J Med Chem. 2023 Jun 22;66(12):8251-8266.
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