OSBPL7-IN-1 |
| رقم الكتالوجGC63339 |
OSBPL7-IN-1 عبارة عن بروتين رابط أوكسيستيرول نشط عن طريق الفم مثل مثبط 7 (OSBPL7)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1269826-44-9
Sample solution is provided at 25 µL, 10mM.
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OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].
OSBPL7-IN-1 (compound G or Cpd G; 1-10 µM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux[1].
OSBPL7-IN-1 (100 mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria and prevents renal function decline in mouse models of proteinuric kidney disease[1].
[1]. Matthew B Wright, et al. Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. Nat Commun. 2021 Aug 2;12(1):4662.
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