OXFBD04 |
| رقم الكتالوجGC39417 |
OXFBD04 هو مثبط قوي وانتقائي BRD4 مع IC50 من 166 نانومترOXFBD04 عبارة عن رابطة برومودومين BET قوية مع تقارب متواضع إضافي لـ CREBBP bromodomainOXFBD04 له نشاط مضاد للسرطان
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Cas No.: 2231747-03-6
Sample solution is provided at 25 µL, 10mM.
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OXFBD04 is a potent and selective BRD4 inhibitor with an IC50 of 166?nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity[1].
[1]. Jennings LE, et al. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorg Med Chem. 2018 Jul 15;26(11):2937-2957.
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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