Pavurutamab |
| رقم الكتالوجGC72443 |
(ديسمبر 2018) Pavurutamab (AMG-701) هو جزيء محفز خلية T ثنائي التحديد الذي هو مستضدات نضج الخلايا المضادة ل CD3 و (BCMA).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2250292-39-6
Sample solution is provided at 25 µL, 10mM.
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Pavurutamab (0-10000 pM; 48 h) induces CD69+, CD25+ T cell activation and IFNγ, TNFα, IL-2, IL-4, IL-6, IL-10 cytokine secretion[5].
Pavurutamab (0.02, 0.2 and 2 mg/kg; i.v.; single dose on days 3, 8, 13) reduces tumor volume with time and dose dependent manner in mouse xenograft models[5].
Pavurutamab (0.005, 0.05 and 0.5 mg/kg; i.v.; every 5 days for 6 administrations, lasting for 30 days) reduces tumor volume and increases survival with time and dose dependent manner in NOD/SCID mice transplanted with L-363 multiple myeloma (MM) cells[5].
References:
[1]. Sheridan C. Bispecific antibodies poised to deliver wave of cancer therapies. Nat Biotechnol. 2021 Mar;39(3):251-254.
[2]. Goldsmith SR, et al. Bispecific Antibodies for the Treatment of Multiple Myeloma. Curr Hematol Malig Rep. 2022 Dec;17(6):286-297.
[3]. Cho SF, et al. The immunomodulatory drugs lenalidomide and pomalidomide enhance the potency of AMG 701 in multiple myeloma preclinical models. Blood Adv. 2020 Sep 8;4(17):4195-4207.
[4]. Harrison S J, et al. A phase 1 first in human (FIH) study of AMG 701, an anti-B-cell maturation antigen (BCMA) half-life extended (HLE) BiTE®(bispecific T-cell engager) molecule, in relapsed/refractory (RR) multiple myeloma (MM)[J]. Blood, 2020, 136: 28-29.
[5]. Goldstein RL, et al. AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys. Blood Adv. 2020 Sep 8;4(17):4180-4194.
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