PCNA-I1 |
| رقم الكتالوجGC44577 |
PCNA-I1 هو مثبط قوي لـ PCNA (مستضد الخلية النووية المتكاثر)يربط PCNA-I1 مباشرة أدوات تشذيب PCNA بـ Kd 0.41 ميكرومتر ويظهر نشاطًا مضادًا للورم في المختبر وفي الجسم الحي
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Cas No.: 444930-42-1
Sample solution is provided at 25 µL, 10mM.
PCNA-I1 is an inhibitor of proliferating cell nuclear antigen (PCNA) that binds to PCNA trimers (Kd = 0.41 µM) and dose-dependently reduces the level of PCNA associated with chromatin in PC3 cells. It preferentially inhibits growth of a variety of human and mouse cancer cell lines (IC50s = 0.05-0.3 µM) over non-transformed cells (IC50s = 0.99-2 µM). PCNA-I1 leads to an accumulation of cells in the G1 phase during the first 24 hours of incubation and halts the cell cycle in the S and G2/M phases by 72 hours following treatment. It also reduces tumor growth in an LNCaP prostate cancer mouse xenograft model when administered at a dose of 10 mg/kg, five days per week, for two weeks.
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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