PD-1/PD-L1-IN 3 TFA |
| رقم الكتالوجGC65071 |
PD-1 / PD-L1-IN 3 TFA ، ببتيد macrocyclic ، هو مثبط قوي وانتقائي لتفاعلات PD-1 / PD-L1 و CD80 / PD-L1 المستخرجة من براءة الاختراع WO2014151634A1 ، المركب رقم 1يتداخل PD-1 / PD-L1-IN 3 TFA مع ربط PD-L1 بـ PD-1 و CD80 من خلال الارتباط بـ PD-L1 ، مع IC50s 5.60 نانومتر و 7.04 نانومتر ، على التوالييمكن استخدام PD-1 / PD-L1-IN 3 TFA للبحث عن أمراض مختلفة ، بما في ذلك السرطان والأمراض المعدية
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC50s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases[1].
PD-1/PD-L1-IN 3 (0.1 nM-10 μM) inhibits the binding of PD-1 and CD80 to PD-L1, with IC50s of 5.60 nM and 7.04 nM[1].PD-1/PD-L1-IN 3 blocks the binding of recombinant PD-L1-Ig to Jurkat-PD-1 cells, and also block binding of recombinant PD-1-Ig to either L2987 or LK35.2-hPD-L1, with IC50s of 26 nM, 12 nM, and 3.5 nM, respectively[1].PD-1/PD-L1-IN 3 (0.001-100 μM) promotes IFN secretion by CMV-specific T cells in a dose-dependent manner, with an EC50 of 400 nM[1].
[1]. MILLER, Michael Matthew, et al. Macrocyclic inhibitors of the pd-1/pd-l1 and cd80(b7-1)/pd-l1 protein/protein interactions. WO2014151634A1.
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