PD-166866 |
| رقم الكتالوجGC19279 |
PD166866 هو مثبط انتقائي لتيروزين كيناز FGFR1 مع IC50 من 52.4 نانومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 192705-79-6
Sample solution is provided at 25 µL, 10mM.
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PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM.
PD 166866 inhibits human full-length FGFR-1 tyrosine kinase with an IC50 value of 52.4 nM and is characterized as an ATP competitive inhibitor of the FGFR-1. PD 166866 is a potent inhibitor of FGFR autophosphorylation in NIH 3T3 cells expressing endogenous FGFR-1 and in L6 cells overexpressing the human FGFR-1 tyrosine kinase. PD 166866 also inhibits bFGF-induced tyrosine phosphorylation of the 44- and 42-kDa (ERK 1/2) mitogen-activated protein kinase isoforms in L6 cells. Daily exposure of PD 166866 to L6 cells at concentrations from 1 to 100 nM results in a concentration-related inhibition of bFGF-stimulated cell growth for 8 consecutive days with an IC50 value of 24 nM[1].
References:
[1]. Panek RL, et al. In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J Pharmacol Exp Ther. 1998 Jul;286(1):569-77.
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