Permethrin-d9 |
| رقم الكتالوجGC91191 |
معيار داخلي لتحديد كمية البيرمثرين
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Permethrin-d9 is intended for use as an internal standard for the quantification of permethrin by GC- or LC-MS. Permethrin is a modulator of voltage-gated sodium channels (NaV) that is used as an insecticide.1 It delays channel deactivation of the NaV1.8 channel expressed in X. laevis oocytes. It is at least 100-fold more potent at insect than mammalian sodium channels, leading to slow deactivation of D. para/TipE, but not rat brain IIA or β1, sodium channels expressed in X. laevis oocytes when used at a concentration of 500 nM.2 Permethrin (5 µM) increases sodium influx in BV-2 and primary microglial cells by approximately 28 and 29%, respectively, and activates microglia.3 Long-term application of permethrin leads to dose- and time-dependent intracellular sodium accumulation and TNF-α release in microglia in vitro. Formulations containing permethrin have been used for the treatment of head lice and scabies infestations.
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