Piperafizine A |
| رقم الكتالوجGC41629 |
Piperafizine A (المركب 4d' ؛) هو مشتق plinabulin N-monoalkylated. كاشف مضاد للسرطان.
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Cas No.: 130603-59-7
Sample solution is provided at 25 µL, 10mM.
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Piperafizine A is a natural methylated diketopiperazine first isolated from an actinomycete, Streptoverticillium. It potentiates the cytotoxicity of vincristine , an anti-cancer alkaloid known to be exported from cells by P-glycoprotein. Piperafizine A directs the intracellular accumulation of vincristine in cancer cells to a similar degree as verapamil , a P-glycoprotein inhibitor. The effects of piperafizine A on vincristine accumulation in cancer cells is dose-dependent over a range of 1 to 20 µg/ml.
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