PluriSIn #2 |
| رقم الكتالوجGC61531 |
يعد PluriSIn # 2 مثبطًا انتقائيًا للنسخ Topoisomerase II α (TOP2A)PluriSIn # 2 هو مركب يزيل بشكل انتقائي الخلايا الجذعية البشرية غير المتمايزة (hPSCs)
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Cas No.: 56563-17-8
Sample solution is provided at 25 µL, 10mM.
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PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1].
PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level[1].A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn't affect the viability of various other cell types derived from them[1]. Western Blot Analysis[1] Cell Line: B153 and HUES9 human pluripotent stem cells (hPSCs)
[1]. Uri Ben-David, et al. Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha. Stem Cells. 2015 Mar;33(3):1013-9.
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