Pomalidomide-amido-C1-Br |
رقم الكتالوجGC39171 |
Pomalidomide-amido-C1-Br عبارة عن اتحاد مركب E3 ligase ligand-linker مُصنَّع يشتمل على يجند cereblon القائم على Pomalidomide ورابطيمكن استخدام Pomalidomide-amido-C1-Br لتصميم آلة إزالة الطرد B-Raf PROTAC PROTAC B-Raf degrader 1. PROTAC B-Raf degrader 1 له نشاط مضاد للسرطان
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Cas No.: 2351106-38-0
Sample solution is provided at 25 µL, 10mM.
Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1. PROTAC B-Raf degrader 1 has anti-cancer activity[1].
[1]. Chen H, et al. Pomalidomide hybrids act as proteolysis targeting chimeras: Synthesis, anticancer activity and B-Raf degradation. Bioorg Chem. 2019 Jun;87:191-199.
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