Pomalidomide-PEG2-azide |
رقم الكتالوجGC61617 |
Pomalidomide-PEG2-azide عبارة عن اتحاد مركب E3 ligase ligand-linker مُصنَّع يشتمل على يجند cereblon القائم على Pomalidomide ورابط PEG المكون من وحدتين المستخدم في تقنية PROTAC
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Cas No.: 2267306-14-7
Sample solution is provided at 25 µL, 10mM.
Pomalidomide-PEG2-azide is a synthetic E3 ligase ligand-linker conjugate that includes a Pomalidomide-based cereblon ligand and a 2-unit PEG linker used in proteolysis targeting chimeras (PROTAC) technology[1]. Pomalidomide-PEG2-azide is a click chemistry reagent containing an azide group that can react with alkynyl-containing molecules via a Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction[2].
Click chemistry is a versatile reaction that can be used for the synthesis of a variety of conjugates. Virtually any biomolecule can be easily labelled with small molecules, such as fluorescent dyes, biotin, etc using click chemistry method.
Click chemistry reaction takes place between two components: azide and alkyne (terminal acetylene). Both azido and alkyne groups are nearly never encountered in natural biomolecules. Hence, the reaction is highly bioorthogonal and specific.
References:
[1] Zhang F, Wu Z, Chen P, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide[J]. Bioorganic & medicinal chemistry, 2020, 28(1): 115228.
[2] Singh M S, Chowdhury S, Koley S. Advances of azide-alkyne cycloaddition-click chemistry over the recent decade[J]. Tetrahedron, 2016, 72(35): 5257-5283.
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