Propargyl-PEG7-NHS ester |
| رقم الكتالوجGC67156 |
Propargyl-PEG7-NHS ester عبارة عن رابط PROTAC قائم على PEG / Alkyl / ether يمكن استخدامه في تخليق PROTACs. إن إستر Propargyl-PEG7-NHS عبارة عن رابط ADC قابل للانقسام يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs).
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Cas No.: 2093152-77-1
Sample solution is provided at 25 µL, 10mM.
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Propargyl-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1.
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