Prostaglandin J2-d4 (Synonyms: PGJ2-d4)

Prostaglandin J₂-d₄ is intended for use as an internal standard for the quantification of prostaglandin J₂ by GC- or LC-MS. Prostaglandin J₂ (PGJ₂) is formed from PGD₂ by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin.¹ PGJ₂ inhibits platelet aggregation with an IC₅₀ of about 5-10 nM.^2,3 PGJ₂ has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines.⁴ However, this activity has been attributed to further metabolites of PGJ₂ and not the parent compound itself.

1.Fitzpatrick, F.A., and Wynalda, M.A.Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitroJ. Biol. Chem.258(19)11713-11718(1983) 2.Bundy, G.L., Morton, D.R., Peterson, D.C., et al.Synthesis and platelet aggregation inhibiting activity of prostaglandin D analoguesJ. Med. Chem.26(6)790-799(1983) 3.Mahmud, I., Smith, D.L., Whyte, M.A., et al.On the identification and biological properties of prostaglandin J2Prostaglandins Leukot. Med.16(2)131-146(1984) 4.Fukushima, M.Prostaglandin J2 - anti-tumor and anti-viral activities and the mechanisms involvedEicosanoids3(4)189-199(1990)