PROTAC FLT-3 degrader 1 |
رقم الكتالوجGC65555 |
PROTAC FLT-3 degrader 1 هو محلل von Hippel-Lindau-based PROTAC FLT-3 internal tandem duplication (ITD) بتركيز IC50 يبلغ 0.6 نانومتر. له نشاط مضاد للاستجابة الخلوية وقدرة على تحفيز البرمجة المُعَدِّية.
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Cas No.: 2230826-81-8
Sample solution is provided at 25 µL, 10mM.
PROTAC FLT-3 degrader 1 is a von Hippel-Lindau-based PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction[1].
[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.
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