Pyridaben (Synonyms: BAS 300, Damanlin, GWN 1715, NC 129)

Pyridaben is a METI acaricide that inhibits mitochondrial electron transport at complex I (METI; K_i = 0.36 nmol/mg protein in rat brain mitochondria).¹ It is active against a variety of mites, inducing 100% mortality of C. malaccensis, D. farina, and T. putrescentia when administered via filter paper contact at doses of 25, 100, and 200 mg/m³, respectively.² Pyridaben is toxic to rats when administered orally (LD₅₀s = 570 and 1,100 for female and male rats, respectively) and via inhalation (LD₅₀s = 0.62 and 0.66 mg/L for female and male rats, respectively).³ Formulations containing pyridaben have been used in the control of mites in agriculture.

1.Navarro, A., BÁndez, M.J., GÓmez, C., et al.Effects of rotenone and pyridaben on complex I electron transfer and on mitochondrial nitric oxide synthase functional activityJ. Bioenerg. Biomembr.42(5)405-412(2010) 2.Takahashi, M., Shono, T., and Umehara, T.Efficacy of pyridaben against three kinds of mites, Cheyletus malaccensis, Dermatophagoides farinae and Tyrophagus putrescentiaeJpn. J. Sanit. Zool.41(3)257-260(1990) 3.Igarashi, H., and Sakamoto, S.Summary of toxicity studies with pyridabenJ. Pest. Scien.19(4)S243-S251(1994)