PZ-II-029 |
رقم الكتالوجGC50375 |
α6β3γ2-selective GABAA positive allosteric modulator
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 164025-44-9
Sample solution is provided at 25 µL, 10mM.
GABAA positive allosteric modulator. Selectively binds with high affinity to α6β3γ2 subunit-containing channels. Inhibits central and peripheral trigeminal responses in a rat migraine model.
Varagic et al (2013) Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors. Br.J.Pharmacol. 169 384 PMID:23472935 |Fan et al (2018) The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation. Neuropharmacology. 140 1 PMID:30016665
Average Rating: 5
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