R-59-949 (Synonyms: Diacylglycerol Kinase Inhibitor II, DKGI-II) |
رقم الكتالوجGC18246 |
R-59-949 هو مثبط باناسيل جلسرين كيناز (DGK) مع IC 50 من 300 نانومتر. R-59-949 يثبط بشدة نشاط النوع الأول DGK α و ويخفف بشكل معتدل نشاط النوع الثاني DGK θ و κ. R-59-949 ينشط بروتين كيناز سي (PKC) عن طريق تعزيز مستويات الليجند الداخلي المنشأ دياسيل جلسرين.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 120166-69-0
Sample solution is provided at 25 µL, 10mM.
R-59-949 is an inhibitor of diacylglycerol kinase α (DGK-α) with an IC50 value of 300 nM in isolated platelet plasma membranes using exogenous diacylglycerol as a substrate. DGK-α inhibition with R-59-949 increases diacylglycerol-dependent PKC activity, serotonin secretion, and aggregation of thrombin-stimulated platelets. R-59-949 inhibits DGK-α activity induced by platelet-derived growth factor (PDGF) in intact vascular smooth muscle cells (VSMCs). It inhibits high K+- and glucose-induced insulin secretion in MIN6 pancreatic β-cells in a dose-dependent manner. In vivo, administration of R-59-949 prevents retinal neovascularization in a mouse model of oxygen-induced retinopathy.
Average Rating: 5
(Based on Reviews and 4 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *